BPTF-IN-BZ1

• CAT Number: I045339
• CAS Number: 2766623-38-3
• Molecular Formula: C13H15ClN4O
• Molecular Weight: 278.74
• Purity: ≥95%
• Synonyms: 5-[4-(2-aminoethyl)anilino]-4-chloro-2-methylpyridazin-3-one
• InChI: InChI=1S/C13H15ClN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
• InChIKey: UOQAFGWMKNIVAR-UHFFFAOYSA-N
• SMILES: CN1C(=O)C(=C(C=N1)NC2=CC=C(C=C2)CCN)Cl

BPTF-IN-BZ1, a BPTF inhibitor, possesses a high potency (Kd = 6.3 nM).

Reference

[1]. Zahid H, et al. New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J Med Chem. 2021 Sep 23;64(18):13902-13917.
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