For research use only. Not for therapeutic Use.
BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease[1].
BPU-11 (100 μM) abolishes the HCN4 cAMP-induced shift in V1/2 with a k1/2 of 0.42 μM[1].
BPU (100 and 200 μM) is specific of the HCN4 isoform and shows no effect on human HCN2 channels expressed in HEK293T cells[1].
| Catalog Number | I012764 |
| CAS Number | 909664-41-1 |
| Synonyms | 1-[1-[(3-cyanophenyl)methyl]piperidin-4-yl]-3-(2-phenylphenyl)-1-(pyridin-3-ylmethyl)urea |
| Molecular Formula | C32H31N5O |
| Purity | ≥95% |
| InChI | InChI=1S/C32H31N5O/c33-21-25-8-6-9-26(20-25)23-36-18-15-29(16-19-36)37(24-27-10-7-17-34-22-27)32(38)35-31-14-5-4-13-30(31)28-11-2-1-3-12-28/h1-14,17,20,22,29H,15-16,18-19,23-24H2,(H,35,38) |
| InChIKey | UIIRFZUAAAFHFB-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1N(CC2=CN=CC=C2)C(=O)NC3=CC=CC=C3C4=CC=CC=C4)CC5=CC(=CC=C5)C#N |
| Reference | [1]. Lolicato M, et al. Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. Nat Chem Biol. 2014 Jun;10(6):457-62. |
