BQ-123 Sodium Salt

• CAT Number: I005254
• CAS Number: 136655-57-7
• Molecular Formula: C₃₁H₄₁N₆O₇•Na
• Molecular Weight: 632.69
• Purity: ≥95%
• Synonyms: Cyclo (D-Trp-D-Asp-Pro-D-Val-Leu) ; Endothelin Receptor A Antagonist BQ-123
• Target: A potent and selective ETA endothelin receptor antagonist
• Solubility: Soluble in water.
• Storage: -20°C
• InChI: InChI=1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,
• InChIKey: FLIKEIGEOXCRRG-DRBUQPBJSA-M
• SMILES: CC(C)CC1C(=O)NC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43

BQ-123 sodium (CAT: I005254) is a potent and selective antagonist of the ETA endothelin receptor. It exhibits a high affinity for the ETA receptor with a Ki value of 1.4 nM while showing a much lower affinity for the ETB receptor (Ki value of 1500 nM). BQ-123 sodium inhibits endothelin-1 (ET-1) receptor binding, preventing Ca²⁺ mobilization, cellular contraction, and activation of MAP kinase. By blocking the ETA receptor, BQ-123 sodium can modulate endothelin signaling. It has potential applications in studying the physiological and pathological roles of endothelin receptors and their involvement in various conditions and diseases.