BQ-788 Sodium Salt

• CAT Number: I001981
• CAS Number: 156161-89-6
• Molecular Formula: C₃₄H₅₀N₅O₇Na
• Molecular Weight: 663.79
• Purity: ≥95%
• Synonyms: N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine, monosodium salt
• Target: Endothelin Receptor
• Solubility: DMSO: ≥ 43 mg/mL
• Storage: Store at -20°C
• IC50: 1.2 nM
• IUPAC Name: sodium;(2R)-2-[[(2R)-2-[[(2S)-2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]-4,4-dimethylpentanoyl]amino]-3-(1-methoxycarbonylindol-3-yl)propanoyl]amino]hexanoate
• InChI: InChI=1S/C34H51N5O7.Na/c1-8-9-16-25(31(42)43)35-29(40)26(18-23-20-38(33(45)46-7)28-17-11-10-15-24(23)28)36-30(41)27(19-34(4,5)6)37-32(44)39-21(2)13-12-14-22(39)3;/h10-11,15,17,20-22,25-27H,8-9,12-14,16,18-19H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43);/q
• InChIKey: QCVIFBRTTLMEOV-FUKQNADPSA-M
• SMILES: CCCCC(C(=O)[O-])NC(=O)C(CC1=CN(C2=CC=CC=C21)C(=O)OC)NC(=O)C(CC(C)(C)C)NC(=O)N3C(CCCC3C)C.[Na+]

BQ-788 Sodium Salt (Cat.No:I001981) is a selective antagonist of endothelin type B (ETB) receptors. It has a high affinity for ETB receptors with an IC50 of 1.2 nM. BQ-788 Sodium Salt has been used in various studies to investigate the role of ETB receptors in cardiovascular and renal systems. It has been shown to have potential therapeutic effects in diseases such as hypertension and chronic kidney disease.

Reference

1: Okada M, Nishikibe M. BQ-788, a selective endothelin ET(B) receptor
antagonist. Cardiovasc Drug Rev. 2002 Winter;20(1):53-66. Review. PubMed PMID:
12070534.
2: Brunner F, Doherty AM. Role of ET(B) receptors in local clearance of
endothelin-1 in rat heart: studies with the antagonists PD 155080 and BQ-788.
FEBS Lett. 1996 Nov 4;396(2-3):238-42. PubMed PMID: 8914994.
3: Sargent CA, Brazdil R, Flynn DA, Brown TJ, Roach AG. Effect of endothelin
antagonists with or without BQ 788 on ET-1 responses in pithed rats. J Cardiovasc
Pharmacol. 1995;26 Suppl 3:S216-8. PubMed PMID: 8587367.
4: Ishikawa K, Ihara M, Noguchi K, Mase T, Mino N, Saeki T, Fukuroda T, Fukami T,
Ozaki S, Nagase T, et al. Biochemical and pharmacological profile of a potent and
selective endothelin B-receptor antagonist, BQ-788. Proc Natl Acad Sci U S A.
1994 May 24;91(11):4892-6. PubMed PMID: 8197152; PubMed Central PMCID: PMC43895.