Br-C10-methyl ester

• CAT Number: I017377
• CAS Number: 6287-90-7
• Molecular Formula: C₁₂H₂₃BrO₂
• Molecular Weight: 279.21
• Purity: ≥95%
• Target: PROTAC Linkers
• Storage: Room Temperature
• IUPAC Name: methyl 11-bromoundecanoate
• InChI: InChI=1S/C12H23BrO2/c1-15-12(14)10-8-6-4-2-3-5-7-9-11-13/h2-11H2,1H3
• InChIKey: HFNPVFKUZYCDIB-UHFFFAOYSA-N
• SMILES: COC(=O)CCCCCCCCCCBr

Br-C10-methyl ester（Cat No.:I017377） is a specific alkyl/ether composition used as a linker in the synthesis of a series of PROTACs (Proteolysis Targeting Chimeras), specifically MS432. PROTACs consist of two distinct ligands connected by a linker. One ligand is designed to bind to the target protein of interest, while the other ligand is intended to recruit an E3 ubiquitin ligase, such as VHL (von Hippel-Lindau protein). The recruitment of the E3 ligase leads to the ubiquitination and subsequent degradation of the target protein, offering a unique approach for targeted protein degradation in drug development.

Reference

[1]. Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.J Med Chem. 2019 Dec 12;62(23):10897-10911.