For research use only. Not for therapeutic Use.
Br-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I044637 |
| CAS Number | 1803547-60-5 |
| Synonyms | 2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]oxane |
| Molecular Formula | C13H25BrO5 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H25BrO5/c14-4-6-15-7-8-16-9-10-17-11-12-19-13-3-1-2-5-18-13/h13H,1-12H2 |
| InChIKey | PITHQIWYWBVVCG-UHFFFAOYSA-N |
| SMILES | C1CCOC(C1)OCCOCCOCCOCCBr |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
