Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT

• CAT Number: I041764
• CAS Number: 2857037-70-6
• Molecular Formula: C36H38BrN5O9
• Molecular Weight: 764.62
• Purity: ≥95%
• Synonyms: (2S)-2-[(2-bromoacetyl)amino]-N-[(2S)-1-[[3-[(5S)-5-ethyl-5-hydroxy-6,10-dioxo-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaen-14-yl]-1-bicyclo[1.1.1]pentanyl]amino]-1-oxopropan-2-yl]-3-methylbutanamide
• InChI: InChI=1S/C36H38BrN5O9/c1-5-36(48)21-7-23-29-19(10-42(23)32(46)20(21)11-49-33(36)47)27(18-6-24-25(51-15-50-24)8-22(18)39-29)34-12-35(13-34,14-34)41-30(44)17(4)38-31(45)28(16(2)3)40-26(43)9-37/h6-8,16-17,28,48H,5,9-15H2,1-4H3,(H,38,45)(H,40,43)(H,41,44)/t17-,28-,34?,35?,36-/m0/s1
• InChIKey: RCIVGZZPQGHOGN-JLVKPTLHSA-N
• SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC6=C(C=C5N=C4C3=C2)OCO6)C78CC(C7)(C8)NC(=O)C(C)NC(=O)C(C(C)C)NC(=O)CBr)O

Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (Formula V) is a agent-linker conjugate that composed of a potent topoisomerase I inhibitor and a linker to make antibody agent conjugate (ADC)[1].
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT can be conjugated to an anti-c-Met antibody to form an anti-c-Met topoisomerase 1 Inhibitorsantibody drug conjugate (ADC)[1].

Reference

[1]. Phillips AC, et, al. Anti-c-met antibody drug conjugates. WO2022232834A1.