bradykinin, Sar-(D-Phe(8))des-Arg(9)

• CAT Number: M116204
• CAS Number: 126959-88-4
• Molecular Formula: C47H66N12O11
• Molecular Weight: 975.12
• Purity: ≥95%
• Synonyms: bradykinin, Sar-(D-Phe(8))des-Arg(9)
• Target: Bradykinin Receptor
• Solubility: Soluble to 2 mg/ml in 30% acetonitrile / sterile water
• Storage: Desiccate at -20C
• IUPAC Name: (2R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
• InChI: InChI=1S/C47H66N12O11/c1-50-26-38(61)53-31(16-8-20-51-47(48)49)43(66)59-23-11-19-37(59)45(68)58-22-9-17-35(58)41(64)52-27-39(62)54-32(24-29-12-4-2-5-13-29)40(63)56-34(28-60)44(67)57-21-10-18-36(57)42(65)55-33(46(69)70)25-30-14-6-3-7-15-30/h2-7,12-15,31-37,50,60H,8-11,16-28H2,1H3,(H,52,64)(H,53,61)(H,54,62)(H,55,65)(H,56,63)(H,69,70)(H4,48,49,51)/t31-,32-,33+,34-,35-,36-,37-/m0/s1
• InChIKey: YIUBSFCQATYQJB-VCMDLEIESA-N
• SMILES: CNCC(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(CC5=CC=CC=C5)C(=O)O

Bradykinin, Sar-(D-Phe(8))des-Arg(9)(CAT: M116204) is a modified bradykinin analog used in biochemical and pharmacological research. This peptide variation includes sarcosine (Sar) at the N-terminal and a D-phenylalanine substitution at position 8, with the arginine residue at position 9 removed (des-Arg(9)). These modifications confer increased stability and altered receptor binding affinity compared to native bradykinin, particularly enhancing selectivity for bradykinin receptors such as B1 or B2, depending on the specific research application. This analog is widely used in studies focused on inflammatory processes, pain pathways, and cardiovascular research, where bradykinin signaling plays a critical role. Bradykinin, Sar-(D-Phe(8))des-Arg(9) provides researchers with a tool for exploring bradykinin receptor mechanisms and potential therapeutic targets in inflammation and pain modulation.