For research use only. Not for therapeutic Use.
Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity[1].
| Catalog Number | I019505 |
| CAS Number | 369631-68-5 |
| Synonyms | 6-methyl-5-nitro-2-(trifluoromethyl)chromen-4-one |
| Molecular Formula | C11H6F3NO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C11H6F3NO4/c1-5-2-3-7-9(10(5)15(17)18)6(16)4-8(19-7)11(12,13)14/h2-4H,1H3 |
| InChIKey | WEUSXIBCGCFOQR-UHFFFAOYSA-N |
| SMILES | CC1=C(C2=C(C=C1)OC(=CC2=O)C(F)(F)F)[N+](=O)[O-] |
| Reference | [1]. Nawrotek A, et al. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3. |
