For research use only. Not for therapeutic Use.
Brassinin (BSN) is a phytoalexin isolated from <em>B. campestris</em> that exhibits anticancer, chemopreventative, antiproliferative, and antifungal activities. Brassinin suppresses constitutive and IL-6-induced STAT3 activation <em>in vitro</em> and attenuates tumor growth in a xenograft lung cancer mouse model through modulation of E3 SUMO-protein ligase 3 (PIAS-3) and suppressor of cytokine signaling-3 (SOCS-3). Brassinin also induces apoptosis in PC3 cells through suppression of PI3K, Akt, mTOR, and S6K1.
| Catalog Number | R004065 |
| CAS Number | 105748-59-2 |
| Synonyms | N-(1H-Indol-3-ylmethyl)carbamodithioic Acid Methyl Ester; Brassinine; |
| Molecular Formula | C11H12N2S2 |
| Purity | ≥95% |
| Target | Disease Research Fields |
| Storage | -20°C |
| IUPAC Name | methyl N-(1H-indol-3-ylmethyl)carbamodithioate |
| InChI | InChI=1S/C11H12N2S2/c1-15-11(14)13-7-8-6-12-10-5-3-2-4-9(8)10/h2-6,12H,7H2,1H3,(H,13,14) |
| InChIKey | QYKQWFZDEDFELK-UHFFFAOYSA-N |
| SMILES | CSC(=S)NCC1=CNC2=CC=CC=C21 |
