For research use only. Not for therapeutic Use.
BRD-6929（Cat No.:I018302）is a selective inhibitor of the bromodomain and extraterminal (BET) family of proteins, which play a critical role in regulating gene expression and chromatin dynamics. By inhibiting BET proteins, BRD-6929 disrupts the interaction between these proteins and acetylated histones, leading to downregulation of oncogenic pathways. This compound has shown potential in preclinical studies for treating various cancers, including leukemia and solid tumors. Ongoing research is focused on its efficacy and safety in clinical trials, as well as its potential applications in combination therapies for enhanced therapeutic outcomes.
| Catalog Number | I018302 |
| CAS Number | 849234-64-6 |
| Molecular Formula | C₁₉H₁₇N₃O₂S |
| Purity | ≥95% |
| Target | Epigenetics |
| IUPAC Name | 4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamide |
| InChI | InChI=1S/C19H17N3O2S/c1-12(23)21-15-7-4-13(5-8-15)19(24)22-17-11-14(6-9-16(17)20)18-3-2-10-25-18/h2-11H,20H2,1H3,(H,21,23)(H,22,24) |
| InChIKey | ABZSPJVXTTUFAA-UHFFFAOYSA-N |
| SMILES | CC(=O)NC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N |
| Reference | [1]. Li-Huei Tsai, et al. Inhibition of hdac2 to promote memory. patent/US20120101147<br>[2]. Schroeder FA, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and altersmouse behavior in two mood-related tests. PLoS One. 2013 Aug 14;8(8):e71323.<br>[3]. Huang L, et al. Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. ACS Med Chem Lett. 2018 Feb 6;9(3):268-273. |
