BRD-K98645985

For research use only. Not for therapeutic Use.

  • CAT Number: I017233
  • CAS Number: 1357647-78-9
  • Molecular Formula: C₃₃H₄₃N₅O₄
  • Molecular Weight: 573.73
  • Purity: ≥95%
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BRD-K98645985(Cat No.:I017233)is a potent, selective inhibitor of the 14-3-3 protein-protein interaction, specifically targeting the interaction between 14-3-3 and its client proteins. This compound plays a crucial role in disrupting the function of 14-3-3 proteins, which are involved in multiple cellular processes such as signal transduction, cell cycle regulation, and apoptosis. Due to its selective inhibition, BRD-K98645985 is an essential tool for studying the mechanistic roles of 14-3-3 in cancer, neurodegeneration, and other diseases. It holds promise for the development of novel therapeutic strategies targeting this protein family.


Catalog Number I017233
CAS Number 1357647-78-9
Molecular Formula C₃₃H₄₃N₅O₄
Purity ≥95%
Target HIV
Storage Store at -20°C
IUPAC Name 1-[(4S,7S,8R)-8-methoxy-4,7,10-trimethyl-11-oxo-5-[(4-pyridin-2-ylphenyl)methyl]-2-oxa-5,10-diazabicyclo[10.4.0]hexadeca-1(12),13,15-trien-14-yl]-3-propan-2-ylurea
InChI InChI=1S/C33H43N5O4/c1-22(2)35-33(40)36-27-14-15-30-28(17-27)32(39)37(5)20-31(41-6)23(3)18-38(24(4)21-42-30)19-25-10-12-26(13-11-25)29-9-7-8-16-34-29/h7-17,22-24,31H,18-21H2,1-6H3,(H2,35,36,40)/t23-,24-,31-/m0/s1
InChIKey DZGZFXRKNSZUSK-MKGJDZFWSA-N
SMILES C[C@H]1CN([C@H](COC2=C(C=C(C=C2)NC(=O)NC(C)C)C(=O)N(C[C@@H]1OC)C)C)CC3=CC=C(C=C3)C4=CC=CC=N4
Reference

[1]. Marian CA, et al. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14.

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