BRD-K98645985

• CAT Number: I017233
• CAS Number: 1357647-78-9
• Molecular Formula: C₃₃H₄₃N₅O₄
• Molecular Weight: 573.73
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 1-[(4S,7S,8R)-8-methoxy-4,7,10-trimethyl-11-oxo-5-[(4-pyridin-2-ylphenyl)methyl]-2-oxa-5,10-diazabicyclo[10.4.0]hexadeca-1(12),13,15-trien-14-yl]-3-propan-2-ylurea
• InChI: InChI=1S/C33H43N5O4/c1-22(2)35-33(40)36-27-14-15-30-28(17-27)32(39)37(5)20-31(41-6)23(3)18-38(24(4)21-42-30)19-25-10-12-26(13-11-25)29-9-7-8-16-34-29/h7-17,22-24,31H,18-21H2,1-6H3,(H2,35,36,40)/t23-,24-,31-/m0/s1
• InChIKey: DZGZFXRKNSZUSK-MKGJDZFWSA-N
• SMILES: CC1CN(C(COC2=C(C=C(C=C2)NC(=O)NC(C)C)C(=O)N(CC1OC)C)C)CC3=CC=C(C=C3)C4=CC=CC=N4

BRD-K98645985（Cat No.:I017233） is a small molecule inhibitor of BAF (mammalian SWI/SNF) transcriptional repression, with an EC50 of ~2.37 µM. It specifically targets ARID1A-containing BAF complexes, prevents nucleosome localization, and effectively reverses HIV-1 latency without T-cell toxicity. BAF complexes are involved in chromatin remodeling, and their dysregulation is implicated in various diseases, including cancer and HIV-1 latency.

Reference

[1]. Marian CA, et al. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14.