For research use only. Not for therapeutic Use.
BRD32048 is a direct binder of ETV1 with a KD of 17.1 μM. BRD32048 modulates both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 inhibits ETV1 acetylation and promotes its degradation. BRD32048 acts as a top candidate ETV1 perturbagen[1].
| Catalog Number | R065291 |
| CAS Number | 433694-46-3 |
| Synonyms | 2-N-(4-methoxyphenyl)-6-(piperidin-1-ylmethyl)-1,3,5-triazine-2,4-diamine |
| Molecular Formula | C16H22N6O |
| Purity | ≥95% |
| InChI | InChI=1S/C16H22N6O/c1-23-13-7-5-12(6-8-13)18-16-20-14(19-15(17)21-16)11-22-9-3-2-4-10-22/h5-8H,2-4,9-11H2,1H3,(H3,17,18,19,20,21) |
| InChIKey | PVHJDJWPRZUURH-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)NC2=NC(=NC(=N2)N)CN3CCCCC3 |
| Reference | [1]. Marius S Pop, et al. A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein. Mol Cancer Ther. 2014 Jun;13(6):1492-502. |
