BRD5529

• CAT Number: I017888
• CAS Number: 1358488-78-4
• Molecular Formula: C₂₅H₃₁N₅O₄
• Molecular Weight: 465.54
• Purity: ≥95%
• Target: E1/E2/E3 Enzyme

BRD5529 is a selective CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction inhibitor with an IC50 of 8.6 μM. BRD5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation and activation of CARD9, and demonstrates cellular activity and selectivity in CARD9-dependent pathways[1].

Reference

[1]. Leshchiner ES, et al. Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatorybowel disease. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11392-11397.