BRD5529

• CAT Number: I017888
• CAS Number: 1358488-78-4
• Molecular Formula: C₂₅H₃₁N₅O₄
• Molecular Weight: 465.54
• Purity: ≥95%
• Target: E1/E2/E3 Enzyme
• IUPAC Name: 2-(4-carbamoyl-4-piperidin-1-ylpiperidin-1-yl)-5-[(4-methylbenzoyl)amino]pyridine-3-carboxylic acid
• InChI: InChI=1S/C25H31N5O4/c1-17-5-7-18(8-6-17)22(31)28-19-15-20(23(32)33)21(27-16-19)29-13-9-25(10-14-29,24(26)34)30-11-3-2-4-12-30/h5-8,15-16H,2-4,9-14H2,1H3,(H2,26,34)(H,28,31)(H,32,33)
• InChIKey: ZXWHESBABUHJBE-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)C(=O)NC2=CC(=C(N=C2)N3CCC(CC3)(C(=O)N)N4CCCCC4)C(=O)O

BRD5529(CAT: I017888) is a selective inhibitor of the CARD9-TRIM62 protein-protein interaction, with an IC₅₀ of 8.6 μM. It directly binds to CARD9, disrupting TRIM62 recruitment and inhibiting TRIM62-mediated ubiquitination and activation of CARD9. This mechanism blocks downstream CARD9-dependent pathways, making BRD5529 an invaluable tool in immunology and inflammation research. Its cellular activity and selectivity allow for precise investigation of CARD9 signaling, which is pivotal in innate immune responses, inflammation, and autophagy. Researchers utilize BRD5529 to explore the therapeutic potential of modulating CARD9 activity in autoimmune diseases, chronic inflammation, and infectious disease models.