BRD9757

• CAT Number: I012759
• CAS Number: 1423058-85-8
• Molecular Formula: C6H9NO2
• Molecular Weight: 127.14
• Purity: ≥95%
• Synonyms: N-hydroxycyclopentene-1-carboxamide
• InChI: InChI=1S/C6H9NO2/c8-6(7-9)5-3-1-2-4-5/h3,9H,1-2,4H2,(H,7,8)
• InChIKey: RYYGSXXWQSXKRP-UHFFFAOYSA-N
• SMILES: C1CC=C(C1)C(=O)NO

BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs[1].
BRD9757 (compound 14) against HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8, and HDAC9 with IC50 values of 0.638 μM, 1.79 μM, 0.694 μM, 21.80 μM, 18.32 μM, 12.61 μM, 1.09 μM, and >33.33 μM, respectively[1].
BRD9757 (compound 14; 10-30 μM; 24 h) selectively increases the level of Ac-tubulin, without increasing histone acetylation[1].

Reference

[1]. Florence F Wagner, et al. Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J Med Chem. 2013 Feb 28;56(4):1772-6.
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