Brepocitinib free base

• CAT Number: I023686
• CAS Number: 1883299-62-4
• Molecular Formula: C18H21F2N7O
• Molecular Weight: 389.41
• Purity: 98%
• Synonyms: PF-06700841; PF 06700841; PF06700841; PF-6700841; PF 6700841; PF6700841; Brepocitinib free base
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
• IUPAC Name: [(1S)-2,2-difluorocyclopropyl](3-{2-[(1-methyl-1Hpyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone
• InChI: InChI=1S/C18H21F2N7O/c1-25-8-11(7-22-25)23-17-21-5-4-15(24-17)26-9-12-2-3-13(10-26)27(12)16(28)14-6-18(14,19)20/h4-5,7-8,12-14H,2-3,6,9-10H2,1H3,(H,21,23,24)/t12?,13?,14-/m0/s1
• InChIKey: BUWBRTXGQRBBHG-RUXDESIVSA-N
• SMILES: O=C([C@H]1C(F)(F)C1)N2C3CN(C4=NC(NC5=CN(C)N=C5)=NC=C4)CC2CC3

Brepocitinib (Cat.No:I023686), also known as PF-06700841, is an inhibitor of JAK1 and TYK2 kinases for potential treatment of systemic lupus erythematosus and plaque psoriasis. PF-06700841 potently inhibits TYK2/JAK2 mediated IL-12/pSTAT4 and IL-23/pSTAT3 (HWB IC50 = 65 and 120 nM, respectively). PF-06700841 improves clinical symptoms of chronic plaque psoriasis by inhibition of proinflammatory cytokines that require TYK2 and Janus kinase 1 for signal transduction.

Reference

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