For research use only. Not for therapeutic Use.
Brevifolincarboxylic acid is extracted from Polygonum capitatum[1], has inhibitory effect on the aryl hydrocarbon receptor (AhR)[2]. Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM[3].
| Catalog Number | M088189 |
| CAS Number | 18490-95-4 |
| Synonyms | 7,8,9-trihydroxy-3,5-dioxo-1,2-dihydrocyclopenta[c]isochromene-1-carboxylic acid |
| Molecular Formula | C13H8O8 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H8O8/c14-5-2-4-7(10(17)9(5)16)8-3(12(18)19)1-6(15)11(8)21-13(4)20/h2-3,14,16-17H,1H2,(H,18,19) |
| InChIKey | JFJWMFPFMLRLMI-UHFFFAOYSA-N |
| SMILES | C1C(C2=C(C1=O)OC(=O)C3=CC(=C(C(=C32)O)O)O)C(=O)O |
| Reference | [1]. Chen X, et al. Simultaneous isolation and purification of gallic acid and brevifolincarboxylic acid from Polygonum capitatum by high-speed counter-current chromatography. Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(15):1957-60. [2]. Amakura Y, et al. Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biol Pharm Bull. 2003 Dec; 26(12):1754-60. [3]. Liu M, et al. Separation of α-glucosidase inhibitors from Potentilla kleiniana Wight et Arn using solvent and flow-rate gradient high-speed counter-current chromatography target-guided by ultrafiltration HPLC-MS screening. Phytochem Anal. 2019 May 6. |
