Brilacidin Tetrahydrochloride

• CAT Number: R014401
• CAS Number: 1224095-99-1
• Molecular Formula: C40H54Cl4F6N14O6
• Molecular Weight: 1082.75
• Purity: ≥95%
• Synonyms: PMX 30063 Tetrahydrochloride; N4,N6-Bis[3-[[5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]-2-[(3R)-3-pyrrolidinyloxy]-5-(trifluoromethyl)phenyl]-4,6-pyrimidinedicarboxamide Hydrochloride
• Target: Bacterial
• Storage: -20°C
• IUPAC Name: 4-N,6-N-bis[3-[5-(diaminomethylideneamino)pentanoylamino]-2-[(3R)-pyrrolidin-3-yl]oxy-5-(trifluoromethyl)phenyl]pyrimidine-4,6-dicarboxamide;tetrahydrochloride
• InChI: InChI=1S/C40H50F6N14O6.4ClH/c41-39(42,43)21-13-25(57-31(61)5-1-3-9-53-37(47)48)33(65-23-7-11-51-18-23)27(15-21)59-35(63)29-17-30(56-20-55-29)36(64)60-28-16-22(40(44,45)46)14-26(34(28)66-24-8-12-52-19-24)58-32(62)6-2-4-10-54-38(49)50;;;;/h13-17,20,23-24,51-52H,1-12,18-19H2,(H,57,61)(H,58,62)(H,59,63)(H,60,64)(H4,47,48,53)(H4,49,50,54);4*1H/t23-,24-;;;;/m1..../s1
• InChIKey: QTHBCQCKYVOFDR-PIJQHSLXSA-N
• SMILES: C1CNCC1OC2=C(C=C(C=C2NC(=O)CCCCN=C(N)N)C(F)(F)F)NC(=O)C3=CC(=NC=N3)C(=O)NC4=C(C(=CC(=C4)C(F)(F)F)NC(=O)CCCCN=C(N)N)OC5CCNC5.Cl.Cl.Cl.Cl

Brilacidin Tetrahydrochloride（Cat No.:R014401）is a novel synthetic antimicrobial compound with potent activity against a broad spectrum of pathogens, including Gram-positive and Gram-negative bacteria. It acts by disrupting bacterial cell membranes, leading to cell death. As a host-defense peptide mimic, Brilacidin Tetrahydrochloride shows promise in treating various infections, including those resistant to traditional antibiotics. It has demonstrated potential in clinical studies for both topical and systemic applications, offering a promising therapeutic option for combating multidrug-resistant infections. The tetrahydrochloride salt form enhances its stability and solubility for improved bioavailability in pharmaceutical formulations.