For research use only. Not for therapeutic Use.
Brinzolamide is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion and thus lowers the intraocular pressure in the anterior chamber, presumably by reducing the rate of formation of bicarbonate ions with subsequent reduction in sodium and fluid transport; this alleviates the effects of open-angle glaucoma.
| Catalog Number | A001173 |
| CAS Number | 138890-62-7 |
| Synonyms | AL-4862 |
| Molecular Formula | C12H21N3O5S3 |
| Purity | ≥95% |
| Target | Carbonic Anhydrase |
| Storage | 3 years -20C powder |
| InChIKey | HCRKCZRJWPKOAR-JTQLQIEISA-N |
| Reference | </br>1:Evaluation of the effects on choroidal thickness of bimatoprost 0.03% versus a brinzolamide 1.0%/timolol maleate 0.5% fixed combination. Akyol N, Kalkisim A, Turk A, Kola M, Imamoglu HI.Cutan Ocul Toxicol. 2017 Apr 25:1-7. doi: 10.1080/15569527.2017.1315128. [Epub ahead of print] PMID: 28376651 </br>2:Additive effects and safety of fixed combination therapy with 1% brinzolamide and 0.5% timolol versus 1% dorzolamide and 0.5% timolol in prostaglandin-treated glaucoma patients. Aihara M, Adachi M, Matsuo H, Togano T, Fukuchi T, Sasaki N; JAC Study group†..Acta Ophthalmol. 2017 Apr 3. doi: 10.1111/aos.13401. [Epub ahead of print] PMID: 28371482 </br>3:The 24-Hour Effects of Brinzolamide/Brimonidine Fixed Combination and Timolol on Intraocular Pressure and Ocular Perfusion Pressure. Seibold LK, DeWitt PE, Kroehl ME, Kahook MY.J Ocul Pharmacol Ther. 2017 Apr;33(3):161-169. doi: 10.1089/jop.2016.0141. Epub 2017 Jan 27. PMID: 28129020 </br>4:Effect of prophylactic intraocular pressure-lowering medication (brinzolamide) on intraocular pressure after ranibizumab intravitreal injection: A case-control study. Song S, Yu XB, Dai H.Indian J Ophthalmol. 2016 Oct;64(10):762-766. doi: 10.4103/0301-4738.195006. PMID: 27905340 Free PMC Article</br>5:Comparison of dorzolamide/timolol vs brinzolamide/brimonidine fixed combination therapy in the management of primary open-angle glaucoma. Kozobolis V, Panos GD, Konstantinidis A, Labiris G.Eur J Ophthalmol. 2017 Mar 10;27(2):160-163. doi: 10.5301/ejo.5000826. Epub 2016 Jul 16. PMID: 27445072 </br>6:Effects of Brinzolamide, a Topical Carbonic Anhydrase Inhibitor, on Corneal Endothelial Cells. Nakano T, Inoue R, Kimura T, Suzumura H, Tanino T, Yamazaki Y, Yoshikawa K, Tatemichi M.Adv Ther. 2016 Aug;33(8):1452-9. doi: 10.1007/s12325-016-0373-y. Epub 2016 Jul 6. PMID: 27384190 </br>7:Ocular hypotensive effect of fixed-combination brinzolamide/brimonidine adjunctive to a prostaglandin analog: a randomized clinical trial. Fechtner RD, Myers JS, Hubatsch DA, Budenz DL, DuBiner HB.Eye (Lond). 2016 Oct;30(10):1343-1350. doi: 10.1038/eye.2016.126. Epub 2016 Jul 1. PMID: 27367743 Free PMC Article</br>8:Crystal structure of Brinzolamide: a carbonic anhydrase inhibitor. Zheng H, Lou B.Acta Crystallogr E Crystallogr Commun. 2016 Apr 15;72(Pt 5):692-5. doi: 10.1107/S2056989016006022. eCollection 2016 May 1. PMID: 27308020 Free PMC Article</br>9:In vitro and in vivo corneal effects of latanoprost combined with brimonidine, timolol, dorzolamide, or brinzolamide. Fukuda M, Takeda N, Shibata S, Shibata N, Shibata T, Sugiyama K, Sasaki H.Eur J Pharmacol. 2016 Sep 15;787:43-6. doi: 10.1016/j.ejphar.2016.05.012. Epub 2016 May 12. PMID: 27181069 </br>10:Efficacy and tolerability of brinzolamide/brimonidine suspension and prostaglandin analogs in patients previously treated with dorzolamide/timolol solution and prostaglandin analogs. Lo JS, Pang PM, Lo SC.Clin Ophthalmol. 2016 Mar 31;10:583-6. doi: 10.2147/OPTH.S98607. eCollection 2016. PMID: 27099466 Free PMC Article |
