For research use only. Not for therapeutic Use.
Britannia (Cat No.: I018488), isolated from Inula aucheriana, is a sesquiterpene lactone. Britannia induces apoptosis and autophagy in hepatoma cells by activating AMPK regulated by ROS. Britannia has anti-proliferative and anti-inflammatory activities. If you need, please contact us in time, and we will reply as soon as possible within 24 hours.
| Catalog Number | I018488 |
| CAS Number | 33627-28-0 |
| Molecular Formula | C₁₉H₂₆O₇ |
| Purity | ≥95% |
| Target | Apoptosis; Autophagy |
| Storage | 4°C, protect from light |
| IUPAC Name | [(3aS,5R,5aS,6S,8S,8aS,9S,9aR)-9-acetyloxy-8-hydroxy-5,8a-dimethyl-1-methylidene-2-oxo-4,5,5a,6,7,8,9,9a-octahydro-3aH-azuleno[6,5-b]furan-6-yl] acetate |
| InChI | InChI=1S/C19H26O7/c1-8-6-12-15(9(2)18(23)26-12)17(25-11(4)21)19(5)14(22)7-13(16(8)19)24-10(3)20/h8,12-17,22H,2,6-7H2,1,3-5H3/t8-,12+,13+,14+,15-,16-,17+,19-/m1/s1 |
| InChIKey | JXEGMONJOSAULB-IZZBGLMFSA-N |
| SMILES | CC1CC2C(C(C3(C1C(CC3O)OC(=O)C)C)OC(=O)C)C(=C)C(=O)O2 |
| Reference | [1]. Cui YQ The suppressive effects of Britannin (Bri) on human liver cancer through inducing apoptosis and autophagy via AMPK activation regulated by ROS. Biochem Biophys Res Commun. 2018 Mar 11;497(3):916-923.<br>[2]. Park HH, et al. Britanin suppresses LPS-induced nitric oxide, PGE2 and cytokine production via NF-κB and MAPK inactivation in RAW 264.7 cells. Int Immunopharmacol. 2013 Feb;15(2):296-302.<br>[3]. Moghadam MH, et al. Anti-proliferative activity and apoptotic potential of britannin, a sesquiterpene lactone from Inula aucheriana. Nat Prod Commun. 2012 Aug;7(8):979-80. |
