For research use only. Not for therapeutic Use.
BRITE-338733（Cat No.:I015058） is a highly potent inhibitor of RecA, an ATPase enzyme involved in DNA-dependent processes. It exhibits significant inhibitory activity against RecA with an IC50 value of 4.7 µM. By targeting RecA, BRITE-338733 disrupts its DNA-dependent ATPase activity, which plays a crucial role in various DNA repair and recombination pathways. The inhibition of RecA by BRITE-338733 offers potential therapeutic applications in the field of DNA repair modulation and may contribute to the development of novel treatments for DNA-related disorders and diseases.
| Catalog Number | I015058 |
| CAS Number | 503105-88-2 |
| Molecular Formula | C₂₇H₃₅N₃O₂ |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | 2-[4-(5-ethylfuran-2-yl)-6-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]pyridin-2-yl]-4-methylphenol |
| InChI | InChI=1S/C27H35N3O2/c1-7-20-9-11-24(32-20)18-13-22(21-12-17(2)8-10-23(21)31)29-25(14-18)28-19-15-26(3,4)30-27(5,6)16-19/h8-14,19,30-31H,7,15-16H2,1-6H3,(H,28,29) |
| InChIKey | PKYYVDCUXJXUPN-UHFFFAOYSA-N |
| SMILES | CCC1=CC=C(O1)C2=CC(=NC(=C2)NC3CC(NC(C3)(C)C)(C)C)C4=C(C=CC(=C4)C)O |
| Reference | [1]. Sexton JZ, et al. Novel Inhibitors of E. coli RecA ATPase Activity. Curr Chem Genomics. 2010;4:34-42. Published 2010 May 26. |
