For research use only. Not for therapeutic Use.
BRL-44408 Maleate(CAT: I005011) is a potent and selective α2A-adrenoceptor antagonist with a Ki of 8.5 nM. Known for its pharmacological profile, BRL-44408 maleate exhibits both antidepressant and analgesic effects, making it a valuable compound for neuropsychological and pain-related research. Additionally, it has demonstrated protective properties in models of sepsis-induced organ injury, notably improving acute lung injury following cecal ligation and puncture (CLP). Its selectivity for α2A over other adrenergic receptor subtypes enhances its utility in studying adrenergic system modulation and inflammation pathways, offering promise for therapeutic development in neuroinflammation and critical care research contexts.
| CAS Number | 681806-46-2 |
| Synonyms | (Z)-but-2-enedioic acid;2-(4,5-dihydro-1H-imidazol-2-ylmethyl)-1-methyl-1,3-dihydroisoindole |
| Molecular Formula | C17H21N3O4 |
| Purity | ≥95% |
| IUPAC Name | (Z)-but-2-enedioic acid;2-(4,5-dihydro-1H-imidazol-2-ylmethyl)-1-methyl-1,3-dihydroisoindole |
| InChI | InChI=1S/C13H17N3.C4H4O4/c1-10-12-5-3-2-4-11(12)8-16(10)9-13-14-6-7-15-13;5-3(6)1-2-4(7)8/h2-5,10H,6-9H2,1H3,(H,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChIKey | DDIQGSUEJOOQQQ-BTJKTKAUSA-N |
| SMILES | CC1C2=CC=CC=C2CN1CC3=NCCN3.C(=CC(=O)O)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
