BRL-52537 hydrochloride

• CAT Number: I012758
• CAS Number: 130497-33-5
• Molecular Formula: C18H25Cl3N2O
• Molecular Weight: 391.76
• Purity: ≥95%
• Synonyms: BRL52537 hydrochloride; 2-(3,4-dichlorophenyl)-1-[2-(pyrrolidin-1-ylmethyl)piperidin-1-yl]ethanone hydrochloride
• IUPAC Name: 2-(3,4-dichlorophenyl)-1-[2-(pyrrolidin-1-ylmethyl)piperidin-1-yl]ethanone;hydrochloride
• InChI: InChI=1S/C18H24Cl2N2O.ClH/c19-16-7-6-14(11-17(16)20)12-18(23)22-10-2-1-5-15(22)13-21-8-3-4-9-21;/h6-7,11,15H,1-5,8-10,12-13H2;1H
• InChIKey: NGVLSOWJSUUYDE-UHFFFAOYSA-N
• SMILES: C1CCN(C(C1)CN2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl.Cl

BRL-52537 hydrochloride (Cat No.: I012758) is a highly selective, potent κ-opioid receptor (KOR) agonist with neuroprotective and analgesic properties. It has been extensively studied for its potential in reducing ischemic brain injury, neuroinflammation, and pain modulation. Unlike μ-opioid receptor agonists, BRL-52537 exhibits minimal addictive potential, making it a promising candidate for neuroprotection and pain management. Preclinical studies suggest its efficacy in stroke models, traumatic brain injury, and other neurological disorders, highlighting its therapeutic potential in central nervous system research.