For research use only. Not for therapeutic Use.
Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor with IC50 of 0.2 μM for MAO-A.
In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC50 is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC50 range of Brofaromine is 0.01 μM to 0.1 μM[1].
| Catalog Number | I013542 |
| CAS Number | 63638-91-5 |
| Synonyms | 4-(7-bromo-5-methoxy-1-benzofuran-2-yl)piperidine |
| Molecular Formula | C14H16BrNO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H16BrNO2/c1-17-11-6-10-7-13(9-2-4-16-5-3-9)18-14(10)12(15)8-11/h6-9,16H,2-5H2,1H3 |
| InChIKey | WZXHSWVDAYOFPE-UHFFFAOYSA-N |
| SMILES | COC1=CC(=C2C(=C1)C=C(O2)C3CCNCC3)Br |
| Reference | [1]. Boland A, et al. Pirlindole and dehydropirlindole protect rat cultured neuronal cells against oxidative stress-induced cell death through a mechanism unrelated to MAO-A inhibition. Br J Pharmacol. 2002 Feb;135(3):713-20. |
