For research use only. Not for therapeutic Use.
Bromadoline maleate（Cat No.:I005025）is a synthetic compound that functions as a selective agonist of the kappa-opioid receptor (KOR). It has been investigated for its potential use in pain management and as an analgesic, with a reduced risk of respiratory depression and addiction compared to traditional opioids. Bromadoline maleate is also being explored for its antidepressant and anxiolytic properties, as KOR activation has been associated with mood regulation. While it shows promise as a therapeutic agent, further research is needed to fully understand its efficacy, safety profile, and potential clinical applications in various conditions.
| Catalog Number | I005025 |
| CAS Number | 81447-81-6 |
| Synonyms | Bromadoline; U-47931E; U 47931E; U47931E; U 47,931E; U47,931E; U-47,931E; Bromadoline maleate;4-bromo-N-((1R,2R)-2-(dimethylamino)cyclohexyl)benzamide maleate |
| Molecular Formula | C19H25BrN2O5 |
| Purity | ≥95% |
| Target | µ-opioid receptor agonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term ,or -20 °C for long term |
| IUPAC Name | 4-bromo-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]benzamide;(Z)-but-2-enedioic acid |
| InChI | InChI=1S/C15H21BrN2O.C4H4O4/c1-18(2)14-6-4-3-5-13(14)17-15(19)11-7-9-12(16)10-8-11;5-3(6)1-2-4(7)8/h7-10,13-14H,3-6H2,1-2H3,(H,17,19);1-2H,(H,5,6)(H,7,8)/b;2-1-/t13-,14-;/m1./s1 |
| InChIKey | XHCXKGFNPZETQY-VAYAAYOLSA-N |
| SMILES | CN(C)[C@@H]1CCCC[C@H]1NC(=O)C2=CC=C(C=C2)Br.C(=C\C(=O)O)\C(=O)O |
| Reference | </br>1: Hayes AG, Skingle M, Tyers MB. Evaluation of the receptor selectivities of</br> opioid drugs by investigating the block of their effect on urine output by</br> beta-funaltrexamine. J Pharmacol Exp Ther. 1987 Mar;240(3):984-8. PubMed PMID: 3559988. |
