Bromo-PEG1-acid

• CAT Number: I017001
• CAS Number: 1393330-33-0
• Molecular Formula: C₅H₉BrO₃
• Molecular Weight: 197.03
• Purity: ≥95%
• Target: PROTAC Linkers

Bromo-PEG1-acid (CAT: I017001) is a PEG-based PROTAC linker that plays a crucial role in facilitating the synthesis of PROTAC molecules. With its specific structure, the linker enables the conjugation of different functional groups, allowing for the creation of bifunctional molecules that can simultaneously target specific proteins and induce their degradation. This linker can be strategically incorporated into the design of PROTACs to bridge the target protein and the E3 ligase, promoting the ubiquitination and subsequent degradation of the target protein within the cellular environment.

Reference

[1]. Christopher Michael Semko, et al. C26-linked rapamycin analogs as mtor inhibitors. WO2019212991A1.