For research use only. Not for therapeutic Use.
Bromo-PEG1-C2-azide (Cat.No:I015795) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].<br>PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Catalog Number | I015795 |
CAS Number | 1144106-65-9 |
Molecular Formula | C₄H₈BrN₃O |
Purity | ≥95% |
Target | PROTAC Linkers |
IUPAC Name | 1-azido-2-(2-bromoethoxy)ethane |
InChI | InChI=1S/C4H8BrN3O/c5-1-3-9-4-2-7-8-6/h1-4H2 |
InChIKey | SBVSTNMRZMYOGF-UHFFFAOYSA-N |
SMILES | C(COCCBr)N=[N+]=[N-] |
Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |