Bromo-PEG1-C2-Boc

• CAT Number: I016471
• CAS Number: 1393330-36-3
• Molecular Formula: C9H17BrO3
• Molecular Weight: 253.13
• Purity: ≥95%
• Synonyms: tert-butyl 3-(2-bromoethoxy)propanoate
• InChI: InChI=1S/C9H17BrO3/c1-9(2,3)13-8(11)4-6-12-7-5-10/h4-7H2,1-3H3
• InChIKey: KRGOEVTUVNSLIG-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCBr

Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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