Bromo-PEG1-CH2-Boc

• CAT Number: I016466
• CAS Number: 157759-50-7
• Molecular Formula: C₈H₁₅BrO₃
• Molecular Weight: 239.11
• Purity: ≥95%
• Target: PROTAC Linkers

Bromo-PEG1-CH2-Boc (CAT: I016466) serves as a PEG-based PROTAC linker, playing a crucial role in the synthesis of Proteolysis-Targeting Chimeras (PROTACs). PROTACs are innovative molecules designed to harness the cellular protein degradation machinery for targeted protein removal. This linker acts as a strategic connector, facilitating the conjugation of the ligand that binds to the target protein with the ligand that recruits an E3 ubiquitin ligase, leading to the degradation of the target protein.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562