Bromo-PEG1-CH2COOH

• CAT Number: I016382
• CAS Number: 1135131-50-8
• Molecular Formula: C4H7BrO3
• Molecular Weight: 183.00
• Purity: ≥95%
• Synonyms: 2-(2-bromoethoxy)acetic acid
• InChI: InChI=1S/C4H7BrO3/c5-1-2-8-3-4(6)7/h1-3H2,(H,6,7)
• InChIKey: GBPDANKBFPPRCR-UHFFFAOYSA-N
• SMILES: C(CBr)OCC(=O)O

Bromo-PEG1-CH2COOH is a PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Reference

[1]. Christopher Michael Semko, et al. C26-linked rapamycin analogs as mtor inhibitors. WO2019212991A1.