For research use only, not for therapeutic use.
Bromo-PEG2-alcohol (CAT: I016583) is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. This linker consists of a bromo functional group and a PEG chain, which enable its attachment to different molecules. In the context of PROTAC development, Bromo-PEG2-alcohol serves as a vital component to connect target-binding ligands and E3 ligase-recruiting ligands. This strategic linkage facilitates the creation of chimeric molecules capable of inducing targeted protein degradation. Such PROTACs hold significant promise for applications in drug discovery and the modulation of specific cellular processes across various research fields.
| Catalog Number | I016583 |
| CAS Number | 57641-66-4 |
| Molecular Formula | C₄H₉BrO₂ |
| Purity | ≥95% |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
