Bromo-PEG2-bromide

• CAT Number: I016963
• CAS Number: 31255-10-4
• Molecular Formula: C₆H₁₂Br₂O₂
• Molecular Weight: 275.97
• Purity: ≥95%
• Target: PROTAC Linkers
• Storage: -20°C
• IUPAC Name: 1,2-bis(2-bromoethoxy)ethane
• InChI: InChI=1S/C6H12Br2O2/c7-1-3-9-5-6-10-4-2-8/h1-6H2
• InChIKey: UOWNEWCMPHICQH-UHFFFAOYSA-N
• SMILES: C(COCCBr)OCCBr

Bromo-PEG2-bromide is a PEG-based PROTAC linker commonly employed in the synthesis of proteolysis-targeting chimeras (PROTACs). This linker consists of a polyethylene glycol (PEG) chain connected to two bromide groups. It serves as a spacer between the ligand targeting the protein of interest and the ligand recruiting an E3 ubiquitin ligase, facilitating the degradation of the target protein. Bromo-PEG2-bromide enables the covalent attachment of ligands, allowing the construction of PROTAC molecules with enhanced target specificity and cellular activity.

Reference

[1]. Chen TH, et al. Metal-organic frameworks constructed from crown ether-based 1,4-benzenedicarboxylic acid derivatives. Dalton Trans. 2016 Feb 21;45(7):3063-9.