Bromo-PEG2-C2-azide

• CAT Number: I016362
• CAS Number: 530151-56-5
• Molecular Formula: C₆H₁₂BrN₃O₂
• Molecular Weight: 238.08
• Purity: ≥95%
• Target: PROTAC
• IUPAC Name: 1-azido-2-[2-(2-bromoethoxy)ethoxy]ethane
• InChI: InChI=1S/C6H12BrN3O2/c7-1-3-11-5-6-12-4-2-9-10-8/h1-6H2
• InChIKey: QZCKRLVDTQCBFT-UHFFFAOYSA-N
• SMILES: C(COCCOCCBr)N=[N+]=[N-]

Bromo-PEG2-C2-azide (Cat.No:I016362) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bromo-PEG2-C2-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Reference

[1]. Yong Zu Kim, et al. Antibody-drug conjugates comprising branched linkers and methods related thereto. WO2017089895A1.