For research use only. Not for therapeutic Use.
Bromo-PEG2-C2-Boc is a PEG-based PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This linker consists of a polyethylene glycol (PEG) chain connected to a C2 alkyl spacer and a tert-butyloxycarbonyl (Boc) protected amine group. It serves as a flexible bridge between the ligand targeting the protein of interest and the ligand recruiting an E3 ubiquitin ligase. Bromo-PEG2-C2-Boc enables the construction of PROTAC molecules with improved target specificity and cellular activity by facilitating the covalent attachment of ligands.
| Catalog Number | I016470 |
| CAS Number | 1381861-91-1 |
| Molecular Formula | C₁₁H₂₁BrO₄ |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Storage | 2-8°C |
| IUPAC Name | tert-butyl 3-[2-(2-bromoethoxy)ethoxy]propanoate |
| InChI | InChI=1S/C11H21BrO4/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h4-9H2,1-3H3 |
| InChIKey | UOYAYHGUAATLSG-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)CCOCCOCCBr |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
