For research use only. Not for therapeutic Use.
Bromo-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I045415 |
| CAS Number | 1935075-34-5 |
| Synonyms | 2-(2-bromoethoxy)ethyl methanesulfonate |
| Molecular Formula | C5H11BrO4S |
| Purity | ≥95% |
| InChI | InChI=1S/C5H11BrO4S/c1-11(7,8)10-5-4-9-3-2-6/h2-5H2,1H3 |
| InChIKey | DADINSRJAJTRQY-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)OCCOCCBr |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
