For research use only. Not for therapeutic Use.
Bromo-PEG2-phosphonic acid diethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016524 |
| CAS Number | 1226767-94-7 |
| Synonyms | 1-(2-bromoethoxy)-2-(2-diethoxyphosphorylethoxy)ethane |
| Molecular Formula | C10H22BrO5P |
| Purity | ≥95% |
| InChI | InChI=1S/C10H22BrO5P/c1-3-15-17(12,16-4-2)10-9-14-8-7-13-6-5-11/h3-10H2,1-2H3 |
| InChIKey | BYTKSVRXAWIJCM-UHFFFAOYSA-N |
| SMILES | CCOP(=O)(CCOCCOCCBr)OCC |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
