Bromo-PEG3-CH2-Boc

• CAT Number: I016464
• CAS Number: 2100306-71-4
• Molecular Formula: C₁₂H₂₃BrO₅
• Molecular Weight: 327.21
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: tert-butyl 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]acetate
• InChI: InChI=1S/C12H23BrO5/c1-12(2,3)18-11(14)10-17-9-8-16-7-6-15-5-4-13/h4-10H2,1-3H3
• InChIKey: WDLOTPAWUBQPND-UHFFFAOYSA-N

Bromo-PEG3-CH2-Boc (Cat.No:I016464) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562