For research use only. Not for therapeutic Use.
Bromo-PEG4-acid(CAT: I016472) serves as a versatile PEG-based linker employed in the construction of PROTACs (Proteolysis-Targeting Chimeras). This linker offers a strategic connection point between target-binding ligands and E3 ligase-recruiting moieties, enabling the creation of bifunctional molecules. These PROTACs harness the cellular machinery to induce the ubiquitination and subsequent degradation of disease-related proteins.
| Catalog Number | I016472 |
| CAS Number | 1393330-38-5 |
| Molecular Formula | C₁₁H₂₁BrO₆ |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
