Bromo-PEG4-azide

For research use only. Not for therapeutic Use.

  • CAT Number: I015793
  • CAS Number: 1951439-37-4
  • Molecular Formula: C10H20BrN3O4
  • Molecular Weight: 326.19
  • Purity: ≥95%
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Bromo-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].


Catalog Number I015793
CAS Number 1951439-37-4
Synonyms

1-azido-2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethane

Molecular Formula C10H20BrN3O4
Purity ≥95%
InChI InChI=1S/C10H20BrN3O4/c11-1-3-15-5-7-17-9-10-18-8-6-16-4-2-13-14-12/h1-10H2
InChIKey YICYFFFKHLMTQK-UHFFFAOYSA-N
SMILES C(COCCOCCOCCOCCBr)N=[N+]=[N-]
Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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