For research use only. Not for therapeutic Use.
Bromo-PEG5-alcohol (CAT: I016582) is a PEG-based linker commonly employed in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). This linker plays a crucial role in connecting a target protein-binding ligand and an E3 ligase-recruiting ligand, facilitating the targeted degradation of specific proteins within cells. The bromo group in the linker allows for efficient conjugation reactions, while the polyethylene glycol (PEG) chain contributes to water solubility and favorable pharmacokinetic properties.
| Catalog Number | I016582 |
| CAS Number | 957205-14-0 |
| Molecular Formula | C₁₀H₂₁BrO₅ |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
