Bromo-PEG5-azide

• CAT Number: I015792
• CAS Number: 1402411-90-8
• Molecular Formula: C12H24BrN3O5
• Molecular Weight: 370.24
• Purity: ≥95%
• Synonyms: 1-azido-2-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethane
• InChI: InChI=1S/C12H24BrN3O5/c13-1-3-17-5-7-19-9-11-21-12-10-20-8-6-18-4-2-15-16-14/h1-12H2
• InChIKey: KTOVCBYDDDWFOX-UHFFFAOYSA-N
• SMILES: C(COCCOCCOCCOCCOCCBr)N=[N+]=[N-]

Bromo-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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