For research use only. Not for therapeutic Use.
Bromo-PEG6-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
| Catalog Number | I016884 |
| CAS Number | 72713-23-6 |
| Synonyms | 1,2-bis[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethane |
| Molecular Formula | C14H28Br2O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H28Br2O6/c15-1-3-17-5-7-19-9-11-21-13-14-22-12-10-20-8-6-18-4-2-16/h1-14H2 |
| InChIKey | ODSLOCVIDIOUPB-UHFFFAOYSA-N |
| SMILES | C(COCCOCCOCCBr)OCCOCCOCCBr |
| Reference | [1]. Mulyana Y, et al. Oligonuclear polypyridylruthenium(II) complexes incorporating flexible polar and non-polar bridges: synthesis, DNA-binding and cytotoxicity. Dalton Trans. 2011 Feb 21;40(7):1510-23. [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
