Bromo-PEG7-alcohol

• CAT Number: I045408
• CAS Number: 86220-35-1
• Molecular Formula: C14H29BrO7
• Molecular Weight: 389.28
• Purity: ≥95%
• Synonyms: 2-[2-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
• InChI: InChI=1S/C14H29BrO7/c15-1-3-17-5-7-19-9-11-21-13-14-22-12-10-20-8-6-18-4-2-16/h16H,1-14H2
• InChIKey: PVCTXGYCIVAGIV-UHFFFAOYSA-N
• SMILES: C(COCCOCCOCCOCCOCCOCCBr)O

Bromo-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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