For research use only. Not for therapeutic Use.
Bromoacetamido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016459 |
| CAS Number | 1415800-44-0 |
| Synonyms | 3-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]propanoic acid |
| Molecular Formula | C9H16BrNO5 |
| Purity | ≥95% |
| InChI | InChI=1S/C9H16BrNO5/c10-7-8(12)11-2-4-16-6-5-15-3-1-9(13)14/h1-7H2,(H,11,12)(H,13,14) |
| InChIKey | PIANHFIJCGRNCU-UHFFFAOYSA-N |
| SMILES | C(COCCOCCNC(=O)CBr)C(=O)O |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
