Broussochalcone A

• CAT Number: I042008
• CAS Number: 99217-68-2
• Molecular Formula: C20H20O5
• Molecular Weight: 340.37
• Purity: ≥95%
• Synonyms: (E)-1-[2,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
• InChI: InChI=1S/C20H20O5/c1-12(2)3-6-14-10-15(19(24)11-18(14)23)16(21)7-4-13-5-8-17(22)20(25)9-13/h3-5,7-11,22-25H,6H2,1-2H3/b7-4+
• InChIKey: FEALTYYKRMRXTG-QPJJXVBHSA-N
• SMILES: CC(=CCC1=CC(=C(C=C1O)O)C(=O)C=CC2=CC(=C(C=C2)O)O)C

Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC50=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways[1][2].
Broussochalcone A (0.3, 1, and 3 μM; 10 min, Fe induction for another 30 min) inhibits Fe2+ (200 μM)-induced lipid peroxidation in rat brain homogenate[1].
Broussochalcone A (1-30 μM; 30 min) increases DPPH (100 μM)-scavenging activity dose-dependently[1].
Broussochalcone A (0.1-1 μM) inhibits cytochrome c reduction with an IC50 value of 0.5 μM, mostly due to its superoxide anion-scavenging activity and only partially to its inhibition of xanthine oxidase activity[1].
Broussochalcone A (1-20 μM; 24 h) inhibits nitrite production and iNOS protein expression[1].

Reference

[1]. Cheng Z, et al. Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages. Biochem Pharmacol. 2001 Apr 15;61(8):939-46.
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[2]. Lee HK, et al. Broussochalcone A Induces Apoptosis in Human Renal Cancer Cells via ROS Level Elevation and Activation of FOXO3 Signaling Pathway. Oxid Med Cell Longev. 2021 Oct 27;2021:2800706.
 [Content Brief]