For research use only. Not for therapeutic Use.
Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis[1].
Broussonin E (20 μM, 3 h) inhibits the LPS (Lipopolysaccharides, HY-D1056)-stimulated phosphorylation of ERK and p38 MAPK[1].
Broussonin E can activate janus kinase (JAK) 2, signal transducer and activator of transcription (STAT) 3[1].
Broussonin E (0-20 μM, 3 h) can suppress the LPS-induced pro-inflammatory production in RAW264.7 cells, involving TNF-α, IL-1β, IL-6, COX-2 and iNOS[1].
Broussonin E enhances the expressions of anti-inflammatory mediators such as IL-10, CD206 and arginase-1 (Arg-1) in LPS-stimulated RAW264.7 cells[1].
| Catalog Number | R011036 |
| CAS Number | 90902-21-9 |
| Synonyms | 5-[3-(2-hydroxy-4-methoxyphenyl)propyl]-2-methoxyphenol |
| Molecular Formula | C17H20O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H20O4/c1-20-14-8-7-13(15(18)11-14)5-3-4-12-6-9-17(21-2)16(19)10-12/h6-11,18-19H,3-5H2,1-2H3 |
| InChIKey | GDCSYNUJDYRGRF-UHFFFAOYSA-N |
| SMILES | COC1=CC(=C(C=C1)CCCC2=CC(=C(C=C2)OC)O)O |
| Reference | [1]. Huang SP, et al. Broussonin E suppresses LPS-induced inflammatory response in macrophages via inhibiting MAPK pathway and enhancing JAK2-STAT3 pathway. Chin J Nat Med. 2019 May 20;17(5):372-380. |
