For research use only. Not for therapeutic Use.
Bruceine B inhibits protein synthesis and nucleic acid synthesis[1].
Bruceine B exhibits an IC50 of 10 nM for antimalarial activity[1].
| Catalog Number | R066454 |
| CAS Number | 25514-29-8 |
| Synonyms | methyl (1R,2S,3R,6R,8R,13S,14R,15R,16S,17S)-3-acetyloxy-10,15,16-trihydroxy-9,13-dimethyl-4,11-dioxo-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-17-carboxylate |
| Molecular Formula | C23H28O11 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H28O11/c1-8-10-5-12-22-7-32-23(20(30)31-4,17(22)15(19(29)34-12)33-9(2)24)18(28)14(27)16(22)21(10,3)6-11(25)13(8)26/h10,12,14-18,26-28H,5-7H2,1-4H3/t10-,12+,14+,15+,16+,17+,18-,21-,22+,23-/m0/s1 |
| InChIKey | YDWODLQEUPYKGJ-LZFWDZGBSA-N |
| SMILES | CC1=C(C(=O)CC2(C1CC3C45C2C(C(C(C4C(C(=O)O3)OC(=O)C)(OC5)C(=O)OC)O)O)C)O |
| Reference | [1]. G C Kirby, et al. In vitro studies on the mode of action of quassinoids with activity against chloroquine-resistant Plasmodium falciparum. Biochem Pharmacol. 1989 Dec 15;38(24):4367-74. |
