For research use only. Not for therapeutic Use.
Bruceine E is a quassinoid from seeds of Brucea javanica (L.) Merr, exhibiting hypoglycemia effect[1]. Bruceine E exhibits blood glucose lowering effect in both nondiabetic mice and Streptozotocin (STZ)-induced diabetic rats at lower dose[2].
Bruceine D and E, isolated from B. javanica seeds, exhibits blood glucose lowering effect in both nondiabetic mice and STZ-induced diabetic rats at lower dose (1 mg/kg b.w.) during 0-8 h screening[2].
| Catalog Number | R066462 |
| CAS Number | 21586-90-3 |
| Synonyms | (1R,2R,3R,6R,8S,11S,12S,13S,14R,15R,16S,17R)-2,3,11,12,15,16-hexahydroxy-9,13,17-trimethyl-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-en-4-one |
| Molecular Formula | C20H28O9 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H28O9/c1-7-4-9(21)13(23)17(2)8(7)5-10-19-6-28-18(3,14(24)11(22)12(17)19)20(19,27)15(25)16(26)29-10/h4,8-15,21-25,27H,5-6H2,1-3H3/t8-,9-,10+,11+,12+,13+,14-,15-,17-,18+,19+,20+/m0/s1 |
| InChIKey | ZBXITHPYBBXZRG-QYUWQHSUSA-N |
| SMILES | CC1=CC(C(C2(C1CC3C45C2C(C(C(C4(C(C(=O)O3)O)O)(OC5)C)O)O)C)O)O |
| Reference | [1]. Man F, et al. HPLC-MS/MS method for bioavailability study of bruceines D & E in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 15;1063:183-188. [2]. Ablat A, et al. Antidiabetic effects of Brucea javanica seeds in type 2 diabetic rats. BMC Complement Altern Med. 2017;17(1):94. Published 2017 Feb 6. |
