BS-181 hydrochloride

• CAT Number: I001519
• CAS Number: 1397219-81-6
• Molecular Formula: C22H32N6• HCl
• Molecular Weight: 417.00
• Purity: ≥95%
• Synonyms: 5-N-(6-aminohexyl)-7-N-benzyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine;hydrochloride
• Target: Cyclin-Dependent Kinases
• Solubility: DMSO: 83 mg/ml; Ethanol: 27 mg/ml; Water: 3 mg/ml
• Storage: 3 years -20℃ powder
• IC50: 21 nM
• InChI: InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(19)28)24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2,1-2H3,(H,24,27);1H
• InChIKey: NVIJWMOQODWNFN-UHFFFAOYSA-N
• SMILES: CC(C)C1=C2N=C(C=C(N2N=C1)NCC3=CC=CC=C3)NCCCCCCN.Cl

BS-181 hydrochloride（Cat No.:I001519）is a potent and selective inhibitor of cyclin-dependent kinase 7 (CDK7), an enzyme critical for regulating the cell cycle and transcription. By targeting CDK7, BS-181 hydrochloride effectively inhibits cancer cell growth by disrupting transcriptional activity and inducing apoptosis. It has shown significant promise in preclinical studies, particularly in cancers driven by abnormal CDK7 activity. This compound is valuable in cancer research for studying the role of transcriptional regulation in tumor development and exploring potential targeted therapies for various cancer types.

Reference

[1]. Ali S et al. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 2009 Aug 1;69(15):6208-15.

[2]. Lü XC, Montelius-Alatalo K, Helou K, Klinga-Levan K, Islam Q, Levan G, R?hme D.
SourceDepartment of Genetics, Lundberg Laboratory, G?teborg University, Sweden.Isolation of DNA markers for the rat Sai 1 gene for suppression of anchorage independence by using representational difference analysis.Somat Cell Mol Genet. 1997 Jan;23(1):63-74.

[3]. Islam MQ, Szpirer J, Szpirer C, Islam K, Dasnoy JF, Levan G.A gene for the suppression of anchorage independence is located in rat chromosome 5 bands q22-23, and the rat alpha-interferon locus maps at the same region.J Cell Sci. 1989 Feb;92 ( Pt 2):147-62.