BS-181

• CAT Number: I000382
• CAS Number: 1092443-52-1
• Molecular Formula: C22H32N6
• Molecular Weight: 380.53
• Purity: ≥95%
• Synonyms: 5-N-(6-aminohexyl)-7-N-benzyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine
• Target: Cyclin-Dependent Kinases
• Solubility: DMSO ≥80mg/mL Water ≥2.8mg/mL Ethanol ≥9mg/mL
• Storage: Store at -20°C
• IC50: 21 nM
• InChI: InChI=1S/C22H32N6/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(19)28)24-13-9-4-3-8-12-23/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2,1-2H3,(H,24,27)
• InChIKey: DNYBIOICMDTDAP-UHFFFAOYSA-N
• SMILES: CC(C)C1=C2N=C(C=C(N2N=C1)NCC3=CC=CC=C3)NCCCCCCN

BS-181（Cat No.:I000382）is a selective inhibitor of the enzyme lipoprotein-associated phospholipase A2 (Lp-PLA2), which is implicated in cardiovascular diseases and inflammation. By inhibiting Lp-PLA2, BS-181 reduces the formation of pro-inflammatory mediators and may improve cardiovascular health. This compound has demonstrated anti-inflammatory and lipid-modulating effects, making it a candidate for treating conditions related to atherosclerosis and other vascular diseases. BS-181 has undergone preclinical and clinical evaluations, showing potential in improving lipid profiles and reducing the risk of cardiovascular events, thereby contributing to the development of novel therapeutic strategies in cardiology.

Reference

[1]. Ali S et al. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 2009 Aug 1;69(15):6208-15.
[2]. Lü XC, Montelius-Alatalo K, Helou K, Klinga-Levan K, Islam Q, Levan G, R?hme D. SourceDepartment of Genetics, Lundberg Laboratory, G?teborg University, Sweden.Isolation of DNA markers for the rat Sai 1 gene for suppression of anchorage independence by using representational difference analysis.Somat Cell Mol Genet. 1997 Jan;23(1):63-74.
[3]. Islam MQ, Szpirer J, Szpirer C, Islam K, Dasnoy JF, Levan G.A gene for the suppression of anchorage independence is located in rat chromosome 5 bands q22-23, and the rat alpha-interferon locus maps at the same region.J Cell Sci. 1989 Feb;92 ( Pt 2):147-62.